Amyloid A (AA) amyloidosis is the third most common type of systemic amyloidosis in Australia. However, the majority still remain predominantly of ATTR or AL type with AA cases only constituting 3-5% of systemic amyloidosis cases referred to the AAN clinics1.
Serum amyloid A (SAA) is the constituent protein in AA amyloid deposits and is an acute phase inflammatory protein. AA amyloidosis is strongly associated with chronic inflammation. The most common underlying inflammatory disorders in the “First World” are the chronic inflammatory arthritides followed by the “idiopathic” group then infectious diseases2. In up to 20%-27% of cases, no inflammatory cause is found. Obesity is an emerging associated condition in this “idiopathic” group3.