The name amyloidosis is a collective term for a group of relatively rare and complicated disorders in which abnormal proteins, which have in common an abnormal chemical structure called a beta-pleated sheet, form abnormal amyloid fibrils. These fibrils are relatively insoluble and cannot be broken down easily by the body. They progressively accumulate and deposit within the body’s organs and tissues (except the brain) which without treatment, can lead to organ failure and death.
Most types of amyloidosis are systemic, meaning that the amyloid protein can be deposited in any of the organs and tissues of the body with the exception of the brain.
Organ involvement will vary between the types of amyloidosis and from person to person.
Which organs are involved and to what degree is very important and will influence treatment decisions.
The most critical and fatal manifestation of systemic amyloidosis is cardiac involvement.