There are currently no drug therapies available in Australia to stop the production of the amyloid protein in ATTRv but this may shortly change as a result of recent successful clinical trials of new treatments (see below). Treatments which stabilize the variant transthyretin and prevent it misfolding to form amyloid are becoming available.
Diflunisal is a non-steroidal anti-inflammatory drug (NSAID) that has been shown to bind to the TTR protein in the blood, stabilize it so it cannot misfold, and thereby prevent the formation of the amyloid protein. This delays the progression of neurological impairment. This drug is available through amyloidosis specialists in Australia.
Tafamidis is a TTR stabilizer which has recently been shown in a clinical trial to reduce mortality and cardiovascular-related hospitalizations in ATTRv and ATTRwt. It is becoming available through amyloid specialists in Australia.